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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Cytoskeleton (Hoboken). 2010 Nov 1;67(12):796–807. doi: 10.1002/cm.20489

TABLE 3. Thermal denaturation of dystrophin nano-constructs by circular dichroism (CD) and by Tryptophan fluorescence.

Nano-Construct
(human phenotype)		 CD
Tm(°C)		 %-Helicity, 37°C Tryptophan
fluorescence
in PBS w/TFE Tm (°C)
R16~L1~R21 (Δ45–51)
(Asymptomatic)		 60 54 85 55
R18~L2~R21 (Δ49)
(BMD)		 65 60 70 62
R15~L3~R23 (Δ44–54)
(Mild)		 55 58 75 35
R15~L4~R23 (Δ42–55)
(N/A)		 55 37 n/a n/a

BMD denotes Becker MD, and n/a denotes not addressed.

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