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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep 23;30(12):2482–2486. doi: 10.1161/ATVBAHA.110.211029

Figure 1.

Figure 1

Effects of reducing plasma lipids on valvular calcium deposition (Alizarin Red staining) in A) control mice (CTRL), B) hypercholesterolemic mice (HCHOL), and C) “reversed” mice (REV). Images show valve cusps extending into the lumen of the aorta—arrows highlight corresponding/similar anatomical regions of the valve cusp in each image. Note that there is massive calcification of the aortic valve in HCHOL mice, which can be markedly reduced in a relatively short period of time by reducing blood lipids. D) Quantitation of histological data. * = p < 0.05 versus control mice, † = p < 0.05 versus hypercholesterolemic mice.