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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep 23;30(12):2482–2486. doi: 10.1161/ATVBAHA.110.211029

Figure 3.

Figure 3

Effects of reducing plasma lipids on Runx2, a key regulator of osteoblast differentiation in A) control mice, B) hypercholesterolemic mice, and C) “reversed” mice. D) Quantitation of histological data showing that changes in Runx2 levels parallel P-Smad1/5/8 and β-catenin (both of which can independently drive expression of Runx2). * = p < 0.05 versus control mice, † = p < 0.05 versus hypercholesterolemic mice. Images were acquired using a 60x objective and include only valvular tissue near the base/attachment of the valve.