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. 2010 Dec;88(6):1181–1189. doi: 10.1189/jlb.0410211

Figure 5. P2X receptors and p38 MAPK activation contribute to enhanced T cell activation by HS.

Figure 5.

Jurkat T cells were stimulated for 5 min in the presence or absence of HS (40 mM) and with or without microbeads carrying anti-human CD3 and CD28 antibodies. ERK1/2 and p38 MAPK activation was assessed in the presence or absence of pharmacological inhibition of P2X1 (NF023; 10 μM), P2X1 and P2X4 (TNP-ATP; 30 μM), P2X7 (A-438079; 10 μM), or the general P2 receptor inhibitor suramin (200 μM). Control cells were incubated with isotonic culture medium.