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. 2010 Dec;88(6):1181–1189. doi: 10.1189/jlb.0410211

Figure 7. P2 receptor agonists restore T cell function in the presence of IL-10.

Figure 7.

Jurkat T cells were pretreated with IL-10 (50 pg/ml) for 1 h and then stimulated with microbeads carrying anti-human CD3/CD28 antibodies in the absence or presence of ATP (100 μM), the nonhydrolyzable ATP analog ATPγS (100 μM), the P2X1/P2X7 agonist BzATP (10 μM), or HS (40 mM), and IL-2 mRNA transcription was determined (#P<0.05 compared with CD3/CD28 stimulation; *P<0.05 compared with CD3/CD28 stimulation after IL-10 treatment; two-tailed unpaired Student's t tests; n=3).