Table 3.
The functional annotation categories for the genes regulated by CA IX deficiency.
| Functional category | Total regulated genes | Upregulated genes | Downregulated genes |
|---|---|---|---|
| Developmental processes* | 20 | 13 | 7 |
| Keratinization and keratinocyte differentiation | 8 | 8 | 0 |
| Structural molecule activity | 13 | 13 | 0 |
| Embryo implantation, female pregnancy, and menstrual cycle | 3 | 3 | 0 |
| Rhythmic process | 4 | 3 | 1 |
| Multi-organism process | 5 | 5 | 0 |
| Cell differentiation | 16 | 12 | 4 |
| Serine-type endopeptidase activity, serine hydrolase activity, and serine-type peptidase activity | 9 | 3 | 6 |
| Proteolysis | 15 | 6 | 9 |
| Peptidase activity | 14 | 5 | 9 |
| Endopeptidase activity | 10 | 4 | 6 |
| Trypsin and chymotrypsin activity | 4 | 1 | 3 |
| Hydrolase activity | 22 | 8 | 14 |
| Structural constituent of cytoskeleton | 5 | 5 | 0 |
| Cell communication | 4 | 4 | 0 |
| Metallocarboxypeptidase activity, carboxypeptidase activity, and metalloexopeptidase activity | 3 | 0 | 3 |
| Serine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, and protease inhibitor activity | 4 | 2 | 2 |
| Taxis and chemotaxis | 4 | 3 | 1 |
| Response to external stimulus | 7 | 4 | 3 |
| Immune system process | 10 | 5 | 5 |
| Defense response | 7 | 5 | 2 |
| Positive regulation of cell differentiation | 3 | 2 | 1 |
| PPAR signaling pathway | 3 | 0 | 3 |
| Leukocyte migration | 3 | 2 | 1 |
*A representative category for the following overlapping categories: epidermis morphogenesis, tissue morphogenesis, epidermis development, ectoderm development, tissue development, organ development, anatomical structure development, anatomical structure morphogenesis, cellular developmental process, multicellular organismal development, and epidermal cell differentiation.