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. 2010 Sep 23;11:510. doi: 10.1186/1471-2164-11-510

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Copyright ©2010 Shertz et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The highly conserved FRB domain of Tor. Residues L1971, F1979 and Y2045 are involved in phosphatidic acid binding in mTOR (open arrows). Mutation of S1975 confers rapamycin resistance in mammalian cells, Candida albicans, Cryptococcus neoformans, and Saccharomyces cerevisiae. Residues W2041 and F2048 are required for interaction with rapamycin. All of these amino acid residues are conserved in the species examined in this study. Abbreviations: Sc = Saccharomyces cerevisiae, Sp = Schizosaccharomyces pombe, Po = Pleurotus ostreatus, Mc = Mucor circinelloides, Ro = Rhizopus oryzae, Pb = Phycomyces blakesleeanus, Bd = Batrachochytrium dendrobatidis, Spu = Spizellomyces punctatus.