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. 2010 Sep 27;11:519. doi: 10.1186/1471-2164-11-519

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Copyright ©2010 Choy et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genome-wide conserved consensus motifs (predicted TFBS) are hyper-methylated in human hearts and sperm. Methylation scores were determined across the genome for hearts and sperm using BATMAN [21]. The profiles of these scores (A: hearts, B: sperm) were plotted against locations of conserved consensus motifs for 106 transcription factor families centred on the predicted TF binding site (based on co-ordinates obtained from the UCSC genome web browser: TFBS Conserved track; "set 1", N = 3,749,417 locations). Methylation profile at random genomic locations was analyzed as a negative control and reflects a "neutral" methylation pattern at these locations ("set 2", N = 20,982).