Fig. 8.

Ser/Thr kinase activity does not mediate DTT effects on aged-sAHP. (A) Time course of the change in the normalized sAHP amplitude in the aged animals that were incubated with the broad spectrum Ser/Thr kinase inhibitor H-7 (n = 3) for ≥60 min prior to DTT application. (B) Summary diagram representing the mean percent change in the sAHP amplitude of aged neurons following DTT application under various conditions (filled bars). In each case, the response represents the percent change relative to the preDTT application baseline (dashed line). The numbers above each bar represents the number of neurons recorded in each condition.