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. 2010 Sep 8;104(5):2693–2703. doi: 10.1152/jn.01092.2009

Fig. 4.

Fig. 4.

Cochlear ablation does not affect 5-HT modulation of excitability in P12–P21 rat A1. A: voltage traces from 2 example neurons from sham animals in response to a 100 pA depolarizing current step under different drug conditions (as in Fig. 1). Dashed gray lines indicate resting membrane potential; current injection is shown below the voltage traces. Traces in aCSF and 5-HT are taken from a neuron different from those in wash, KTS, and KTS + 5-HT. B: voltage traces as in A from 2 example neurons from cochlear-ablated animals. C: mean firing rates evoked by depolarizing current injections inform a population of sham rats: aCSF (squares), in the presence of 50 μM 5-HT (blue squares), after wash1 (open squares with dashed line), in 1 μM KTS (green squares), and in KTS + 5-HT (red squares). Neither serotonin nor ketanserin changed the firing rate. In the presence of ketanserin, serotonin significantly decreased firing rate. D: data for cochlear-ablated rats, in the same format as that in C.