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. 2010 Sep 8;104(5):2766–2777. doi: 10.1152/jn.00491.2010

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Fig. 7. — Pretreatment with 2AG or capsaicin occluded further depression. A: bar graph representing the effects of synaptic transmission with and without LFS [control (VEH); w/LFS (VEH)] compared with occlusions with 2AG pretreatment (2AG/LFS occlusion, n = 7) and capsaicin pretreatment (capsaicin/LFS occlusion, n = 5). Data were analyzed through a 1-way ANOVA [F(3,20) = 18.16; P < 0.01] for main treatment effect. Control groups had no change between pre- and posttest values, while LFS groups had a decrease in EPSP posttest amplitude. Pre- and posttest normalized values in the 2AG/LFS (n = 7) and capsaicin/LFS (n = 5) occlusion groups did not have an overall change. Pretest values were depressed due to 2AG or capsaicin pretreatment and subsequent LFS did not induce further depression, resulting in no change in posttest values. Newman-Keuls post hoc analysis detected a significant difference between the w/LFS (VEH) group and the control (VEH; P < 0.05*) group and between the LFS (veh) group with the 2AG/LFS occlusion (P < 0.05*) group and capsaicin/LFS occlusion (P < 0.05*) group. B: bar graph comparing occlusion experiments in control groups, control (VEH), 2AG alone (2AG), capsaicin alone (capsaicin), 2AG pretreatment with subsequent capsaicin application (2AG/capsaicin occlusion, n = 4), or capsaicin pretreatment with subsequent 2AG application (capsaicin/2AG occlusion, n = 5). Data were analyzed through a one-way ANOVA [F(4,29) = 11.99; P < 0.01] for main treatment effect. Control groups had no change between pretest and posttest values, while 2AG and capsaicin groups had a decrease in EPSP posttest amplitude. Pre- and posttest normalized values in the 2AG/capsaicin and capsaicin/2AG occlusion groups did not have an overall change leading to no change in normalized values. In the occlusion groups, pretest EPSPs were depressed after capsaicin or 2AG pretreatment and subsequent drug applications did not induce further depression, resulting in no change in posttest values. Newman-Keuls posthoc analysis detected a significant difference between the control (VEH) and 2AG (P < 0.05*) group and between the 2AG group with the 2AG/capsaicin occlusion (P < 0.05*) group and capsaicin/2AG occlusion (P < 0.05*) group. There was also a significant difference between the control (VEH) group and the capsaicin alone (P < 0.05**) groups and between the capsaicin group with the 2AG/capsaicin occlusion (P < 0.05**) group and capsaicin/2AG occlusion (P < 0.05**) group.