Table 2. Transport study of adsorptively HI 6 dichloride monohydrate-loaded nanoparticles on an in vitro BBB model.
[NP], [drug-loading] | NP-ApoE | NP-PEG | free HI 6-DCL | ||
standardized [oxime](µM) | transport difference(%) | standardized [oxime](µM) | transport difference(%) | standardized [oxime](µM) | |
0.52 mg NP/cm2, 100 µM | 25.76 | +41.46 | 17.41 | −4.39 | 18.21 |
0.52 mg NP/cm2, 1000 µM | 61.81 | +136.73 | 46.22 | +77.02 | 26.11 |
0.26 mg NP/cm2, 100 µM | 24.96 | −3.89 | 5.13 | 80.25 | 25.97 |
0.26 mg NP/cm2, 1000 µM | 67.97 | +100.68 | 26.57 | +26.57 | 33.87 |