Figure 2. Effects of angiotensin II treatment on left cardiac ventricle PDE specific activities.

cAMP-PDE specific activities and contribution of PDE2, PDE3 and PDE4 (A). cGMP-PDE specific activities and contributions of PDE1, PDE2, PDE3 and PDE5 (B). cAMP-PDE over cGMP-PDE total activity ratio (C). Specific activities were determined on total homogenate and expressed as pmol.min⁻¹.mg⁻¹ of protein. Effects on treated rats (▪; n = 4) were compared with control rats (□; n = 6). n.s.: not significant; *: P<0.05; **: P<0.01; ***: P<0.001.