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. 2010 Dec 3;5(12):e15193. doi: 10.1371/journal.pone.0015193

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) TH immunostaining indicates that METH administration augments the reduction in THir in the SNpr of Nurr1 +/−, compared to +/+ mice following repeated METH binge treatment. Calibration bar = 500 um. (B) THir fiber density analysis indicated METH treatment (1xMETH) reduced THir fiber density in SNpr in +/+ and +/− mice (p<0.001, Two-way ANOVA) and repeated METH binge treatment (2XMETH) further reduced THir fiber density in SNpr (p<0.001, Two-way ANOVA). A trend of greater reduction in TH immunoreactivity was found in the Nurr1 +/− mice following 1XMETH (p = 0.058, Two-way ANOVA, post hoc Newman-Keuls test) and a significant decrease in THir in SNpr was found in Nurr1 +/− mice following repeated METH treatment (2XMETH). (p<0.05, Two-way ANOVA, post hoc Newman-Keuls test).