Table 1. Demographics.
Demographic and baseline cognitive characteristics of the 123 subjects in the cohort
| Characteristic | Summary | HR (95% CI)a | Pb |
|---|---|---|---|
| Gender, no. (%) | 0.05 | ||
| Women | 51 (41.5) | 1.8 (1.0, 3.0) | |
| Men | 72 (58.5) | 1.0 | |
| Age at MRI, years | 1.1 (0.9, 1.3) | 0.47 | |
| Median (IQR) | 77 (72, 83) | ||
| Range | 55 to 94 | ||
| Education level, years | 1.0 (0.9, 1.1) | 0.98 | |
| Median (IQR) | 15 (12, 17) | ||
| Range | 7 to 21 | ||
| Apolipoprotein E, no. (%)c | 0.04 | ||
| ε4 carrier | 59 (50.9) | 1.8 (1.0, 3.1) | |
| ε4 non-carrier | 57 (49.1) | 1.0 | |
| White matter hyperintensity | 1.0 (0.8, 1.3) | 0.99 | |
| load, cm3 | |||
| Median (IQR) | 12 (6, 25) | ||
| Range | 1 to 110 | ||
| Cortical infarctions, no. (%) | |||
| Present | 9 (7.3) | 1.2 (0.4, 3.8) | 0.78 |
| Absent | 114 (92.7) | 1.0 | |
| Subcortical infarctions, no. (%) | |||
| Present | 11 (8.9) | 0.47 (0.1, 1.5) | 0.16 |
| Absent | 112 (91.1) | 1 | |
| MMSE at baseline | 1.2 (1.1, 1.3) | 0.002 | |
| Median (IQR) | 27 (25, 28) | ||
| Range | 18 to 30 | ||
| CDR sum of boxes at baseline | 1.5 (1.3, 1.9) | <0.001 | |
| Median (IQR) | 0.5 (0.5, 1.5) | ||
| Range | 0 to 6.5 | ||
| AVLT sum of trials 1–5d | 1.4 (1.2, 1.6) | <0.001 | |
| Median (IQR) | 28 (24, 34) | ||
| Range | 7 to 48 |
a
Hazard ratios for age based on a 5-year increase, for education based on a 1-year decrease; for white matter hyperintensity load based on a 1-unit increase on the natural log scale; for MMSE based on a 1-unit decrease; for CDR sum of boxes based on a 1-unit increase; for AVLT sum of trials 1–5 based on a 5-unit decrease
b
P-value based on 1 degree of freedom likelihood ratio test
c
APOE unavailable in 5 subjects
d
AVLT unavailable in 1 subject
Abbreviations: HR, hazard ratio; IQR, interquartile range; MMSE, Mini Mental State Exam; CDR, Clinical Dementia Rating; AVLT, Auditory Verbal Learning Test