Table. Effects of regional hypometabolism on prosocial sentiment impairment.

Relationship between regional PET hypometabolism and impaired prosocial or other-critical sentiments were assessed using multiple regression analyses. Prosocial effects were evaluated by entering prosocial scores as the variable of interest, and other -critical and dementia scores as covariates. Other-critical effects were evaluated by entering other -critical scores as the variable of interest, and prosocial and dementia scores as covariates. Results of FWE-correction over a priori regions of interest defined on the basis of previous studies are reported (see Methods).

	Cluster (k)	p (FWE-cor)	T	p (unc)	MNI local maxima (x, y, z)
Prosocial
FPC (BA 10)	51	0.009	3.71	0.001	4	68	22
Septal region	23	0.047	2.27	0.018	2	0	6
Other-critical
dmPFC (BA 8/9)	38	0.016	3.38	0.002	4	48	40
Amygdala	34	0.022	2.82	0.006	20	6	−18