Table 2.
Admixture maximum likelihood (AML) p-values for trend corresponding to nine pathways involved in DNA repair. The outcome, breast cancer, was considered generally and with respect to estrogen receptor (ER) and progesterone receptor (PR) subtypes.
| Pathway | Genes | SNPs | BC P trend | ER+ P trend | ER− P trend | PR+ P trend | PR− P trend |
|---|---|---|---|---|---|---|---|
| BER | 11 | 178 | 0.151 | 0.032 | 0.451 | 0.049 | 0.656 |
| DIRECT | 1 | 58 | 0.924 | 0.865 | 0.143 | 0.958 | 0.256 |
| HR | 13 | 352 | 0.606 | 0.582 | 0.36 | 0.702 | 0.331 |
| FAN | 6 | 74 | 0.177 | 0.209 | 0.901 | 0.191 | 0.524 |
| MMR | 7 | 124 | 0.416 | 0.288 | 0.92 | 0.416 | 0.724 |
| NER | 14 | 291 | 0.105 | 0.446 | 0.048 | 0.436 | 0.155 |
| NH | 6 | 109 | 0.93 | 0.946 | 0.43 | 0.553 | 0.002 |
| POL | 5 | 64 | 0.568 | 0.953 | 0.212 | 0.983 | 0.245 |
| REG | 5 | 64 | 0.883 | 0.99 | 0.502 | 0.944 | 0.598 |