Figure 1. TDP-43 pathology observed in FTLD and phosphopeptide enrichment strategy.
Immunohistochemical analyses of FTLD and control cases using a pan-TDP-43 (A and B) or a phosphospecific TDP-43 Ser(409/410) antibody in FTLD (C). (D) Flowchart of experimental design to enrich phosphopeptides from human brain tissue. IHC, immunohistochemistry.