Table 2.
Comparison of histomorphological criteria of allograft injury and markers of humoral rejection between T-cell predominant (CD68/CD3 ratio <1) and MO predominant (CD68/CD3 ratio >1) cases
| Overall n = 34 (100) |
CD68/CD3<1 n = 16 (47) |
CD68/CD3>1 n = 18 (53) |
P-value | |
|---|---|---|---|---|
| Banff ’05 criteria | ||||
| g >0 | 17 (50) | 6 (38) | 11 (61) | ns |
| i >0 | 30 (88) | 15 (98) | 15 (83) | ns |
| t >0 | 30 (88) | 14 (88) | 16 (89) | ns |
| v >0 | 34 (100) | 16 (100) | 18 (100) | ns |
| ah >1 | 1 (3) | 1 (6) | 0 | ns |
| cg >1 | 0 | 0 | 0 | |
| ci >1 | 1 (3) | 0 | 1 (6) | ns |
| ct >1 | 0 | 0 | 0 | |
| cv >1 | 2 (6) | 1 (6) | 1 (6) | ns |
| mm | 1 (3) | 0 | 1 (6) | ns |
| Peritubular capillaritis | 30 (88) | 15 (94) | 15 (83) | ns |
| Interstitial rejection (>i1 and >t1) | 1 (3) | 0 | 1 (6) | ns |
| Other lesions | ||||
| Thrombotic microangiopathy | 6 (18) | 1 (6) | 5 (28) | ns |
| Oedema | 20 (59) | 6 (38) | 14 (78) | ns |
| Acute tubular necrosis | 19 (56) | 8 (50) | 11 (61) | ns |
| C4d staining | ||||
| C4d positivity in PTC | 6 (18) | 3 (19) | 3 (17) | ns |
| C4d positivity in glomeruli | 13 (38) | 7 (44) | 6 (34) | ns |
| C4d positivity in arteries | 2 (6) | 1 (6) | 1 (6) | ns |
PRA, panel-reactive antibodies; PTC, peritubular capillaries; ns, not significant.
Data are given as counts and percentages (in brackets) or median and interquartile range (range from the 25th to the 75th percentile).