Plasma should be rapidly transfused with a dose of 15–20 ml/kg body weight in patients with severe acute blood loss and apparent or impending diffuse microvascular bleeding that is caused in part by coagulopathy with PT < 50% or aPTT > 45 s and/or fibrinogen levels of <1 g/l.	1 C
Plasma shall not be transfused postoperatively as prophylaxis in patients undergoing cardiopulmonary bypass surgery if PT >50% and fibrinogen levels >1 g/l and in the absence of diffuse microvascular bleeding.	1 A