Factor replacement on demand shall be performed during spontaneous or traumatic bleeding episodes at any bleeding site if the bleeding exceeds a minimum degree (e.g. minor skin bleeding) [40, 57].	1C+
Full-time prophylactic replacement therapy shall be carried out mostly in children and adolescents with severe hemophilia in the form of physician-controlled self-administered treatment with the main intention of preventing hemophilic arthropathy [23, 30, 41, 51, 67, 69].	1A
Full-time prophylactic replacement therapy can be carried out individually in adults with the intention of preventing the development of arthropathies as a late consequence [33, 18, 23, 50].	2C+
Prophylactic therapy to prevent bleeding shall be provided before and after surgical interventions.	1C+
Temporary prophylactic therapy to prevent bleeding should be provided during periods of major physical or psychic stress (e.g. rehabilitation, exams) [61, 63].	1C