Fibrinogen can be substituted perioperatively in interventions or lesions with the risk of acute bleeding and confirmed fibrinogen deficiency (massive transfusion, dilution and loss coagulopathy).	2 C+
Fibrinogen can be substituted in synthesis disorders (liver damage) with fibrinogen deficiency or in hemorrhagic dysfibrinogenemias as prophylaxis and therapy of hemorrhage and confirmed fibrinogen deficiency.	2 C+
Fibrinogen can be substituted as a prophylaxis and therapy of hemorrhage and confirmed fibrinogen deficiency of different origin (e.g. acute leukemia, asparaginase therapy, obstetrical complications, postoperatively).	2 C+