Table 9.2.
Prophylactic application of specific immunoglob-ulins for RhD
| Target group/indications/mode of exposition | Preparation | Current evaluation of indication |
|---|---|---|
| Rh(D)-negative (dd) women | ||
| After delivery of an Rh-positive child | anti-D imIg | prescribed post partum prophylaxis |
| During pregnancy | anti-D imIg | ante partum prophylaxis |
| In abortion, after interruption, ectopic pregnancy, amniocentesis, chorion biopsy or cord puncture, in bleeding during pregnancy, after forced inversion, after removal of a hydatid mole, in placenta praevia | anti-D imIg | prescribed prophylaxis |
| Rh(D)-incompatible RBC transfusion; granulocyte transfusion Prophylaxis for immunization against D in Rh-negative (dd) recipients of Rh-positive (D+) RBC or granulocyte concentrates | anti-D ivIg | individual cases, for prevention of anti-D formation, especially for women of reproductive age; not applicable in emergency transfusion |
| Rh (D)-positive platelet transfusion in Rh(D)- negative (dd) women | anti-D ivIg | individual cases, for prevention of anti-D formation, especially for women of reproductive age; not applicable in emergency transfusion |
| ITP | anti-D ivIg | second-line therapy after ivIg; ineffective |
| anti-D s.c. [83] | after splenectomy [17, 106]; caution: hemolysis, hemoglobinuria [42]! | |