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Changing physiology and clinical complications in the natural history of type 2 diabetes. Data extrapolated. Adapted from: Holman RR. Diabetes Res Clin Pract 1998; 40 (Suppl.): S21–5 [162]; Ramlo-Halsted BA, Edelman SV. Prim Care 1999; 26: 771–89 [163]; Nathan DM. N Engl J Med 2002; 347: 1342–9 [164]
