Table 2.
PK parameters from non-compartmental analysis after a-5 min intravenous infusion of 4 g piperacillin
| Average ± SD | Median (Min-Max) | |
|---|---|---|
| Peak concentration (mg l−1) | 463 ± 127 | 465 (279–775) |
| Time to peak (min) | 6.8 ± 2.5 | 5 (5–11) |
| Total clearance (l h−1) | 11.9 ± 1.34 | 11.9 (9.87–14.4) |
| Renal clearance (l h−1) | 7.59 ± 0.86 | 7.81 (5.31–8.78) |
| Nonrenal clearance (l h−1) | 4.33 ± 1.07 | 4.57 (2.21–6.30) |
| Volume of distribution at steady-state (l) | 12.7 ± 2.26 | 12.2 (9.47–16.9) |
| Fraction excreted unchanged in urine (%) | 63.9 ± 6.7 | 63.8 (52.8–79.8) |
| Terminal half-life (h) | 1.22 ± 0.461 | 1.04 (0.693–2.23) |
| Mean residence time (h) | 1.06 ± 0.15 | 1.01 (0.92–1.45) |