Figure 1.

Mean rivaroxaban plasma concentration–time curves on a semi-logarithmic scale in healthy controls (CL_Cr≥80 ml min⁻¹; n= 8) and subjects with mild renal impairment (CL_Cr 50–79 ml min⁻¹, n= 8), moderate renal impairment (CL_Cr 30–49 ml min⁻¹, n= 8) and severe renal impairment (CL_Cr <30 ml min⁻¹, n= 8) after the administration of a single 10 mg dose of rivaroxaban. CL_Cr, creatinine clearance. Healthy controls (CL_Cr≥80 ml min⁻¹) (); Mild renal impairment (CL_Cr 50–79 ml min⁻¹) (- - -); Moderate renal impairment (CL_Cr 30–49 ml min⁻¹) (); Severe renal impairment (CL_Cr <30 ml min⁻¹) ()