Table 1.
Summary of characteristics of all subjects included in the study (n= 32) by degree of renal impairment based on creatinine clearance rates
| Renally impaired groups | |||||
|---|---|---|---|---|---|
| Healthy controls* (n= 8) | Mild impairment† (n= 8) | Moderate impairment‡ (n= 8) | Severe impairment§ (n= 8) | All subjects (n= 32) | |
| Male/female (n) | 5/3 | 5/3 | 4/4 | 4/4 | 18/14 |
| Age (years) | 51.3 ± 8.7 | 49.4 ± 7.7 | 54.9 ± 10.5 | 51.8 ± 9.9 | 51.8 ± 9.0 |
| Weight (kg) | 76.6 ± 12.6 | 80.8 ± 16.6 | 75.3 ± 9.9 | 72.5 ± 12.7 | 76.3 ± 12.9 |
| Height (cm) | 168.0 ± 6.7 | 173.1 ± 11.3 | 170.6 ± 7.1 | 170.3 ± 7.7 | 170.5 ± 8.2 |
| BMI (kg m−2) | 27.0 ± 2.8 | 26.8 ± 4.0 | 25.9 ± 3.4 | 25.0 ± 4.6 | 26.2 ± 3.7 |
| CLCr (ml min−1) | 117.1 ± 29.3 | 66.5 ± 8.1 | 42.6 ± 5.0 | 22.2 ± 4.6 | 62.7 ± 39.4 |
Data are given as mean ± SD, unless indicated otherwise.
*
Measured CLCr≥80 ml min−1.
†
Measured CLCr 50–79 ml min−1.
‡
Measured CLCr 30–49 ml min−1.
§
Measured CLCr <30 ml min−1.
BMI, body mass index; CLCr, creatinine clearance.