Table 3.
Parameter estimates for the final model
| NONMEM | Bootstrap analysis | |||
|---|---|---|---|---|
| Parameter | Estimate | 95% CI | Estimate | 95% CI |
| θ1 | 1.92 × 10−3 | 1.72 × 10−3; 2.12 × 10−3 | 1.93 × 10−3 | 1.72 × 10−3; 2.14 × 10−3 |
| θ2 | 0.650 | 0.391; 0.909 | 0.665 | 0.392; 0.939 |
| θ3 | 0.572 | 0.505; 0.639 | 0.572 | 0.490; 0.654 |
| θ4 | 0.344 | 0.242; 0.446 | 0.340 | 0.200; 0.480 |
| ωCL (CV%) | 35.6 | 28.8; 41.3 | 35.7 | 29.4; 42.0 |
| ωVd (CV%) | 19.3 | 0.8; 27.3 | 20.0 | 0.5; 39.7 |
| σ (µg ml−1) | 2.69 | 0.73; 3.73 | 2.45 | 1.32; 3.58 |
95% CI 95% confidence interval; wt weight (kg); PMA postmenstrual age (weeks); AMX amoxicillin-clavulanic acid; SPI spironolactone; ωCL interindividual variability in CL; ωVd interindividual variability in Vd; σ residual variability. TVCL = (θ1× PMA × (1 +θ2× AMX)) × wt: typical population value for clearance (l h−1); TVV = (θ3× (1 −θ4× SPI)) × wt: typical population value for volume of distribution (l).