Table 5.

Proposed vancomycin dose regimen in typical neonates designed to achieve a peak concentration not exceeding 20 µg ml^-1 and a trough concentration of 7.5 µg ml^-1

		Concomitant therapy
PMA (weeks)	Dose/dosing interval ((mg kg−1)/h)	Amoxicillin-clavulanic acid dose/dosing interval ((mg kg−1)/h)	Spironolactone dose/dosing interval ((mg kg−1)/h)
25	8.5/12	10.0/8	6.5/8
26	8.5/12	10.0/8	6.5/8
27	9.0/12	10.5/8	7.0/8
28	9.5/12	11.0/8	7.0/8
29	9.5/12	11.5/8	7.5/8
30	10.0/12	11.5/8	7.5/8
31	10.5/12	12.0/8	8.0/8
32	11.0/12	13.0/8	8.0/8
33	11.5/12	13.0/8	8.0/8
34	12.5/12	13.0/8	8.0/8
35	13.0/12	13.5/8	8.5/8
36	13.5/12	14.0/8	9.0/8
37	14.0/12	14.5/8	9.5/8
38	9.5/8	15.5/8	9.5/8
39	9.5/8	16.0/8	10.0/8
40	10.0/8	16.5/8	10.5/8
41	10.5/8	17.5/8	11.0/8
≥42	11.0/8	18.5/8	11.5/8

PMA postmenstrual age (weeks).