Table 2.
Baseline demographics and characteristics
| Hepatic impairment group | ||||
|---|---|---|---|---|
| Healthy | Mild | Moderate | Severe | |
| Male/female (n) | 3/3 | 4/2 | 3/3 | 4/2 |
| Age (years) | 43.8 (13.5) | 44.5 (12.7) | 53.2 (6.6) | 49.8 (10.4) |
| Weight (kg) | 79.0 (11.9) | 75.4 (18.0) | 77.5 (21.6) | 74.8 (15.5) |
| BMI (kg m−2) | 27.0 (1.7) | 27.1 (5.2) | 27.9 (5.2) | 25.9 (4.4) |
| Albumin (g dl−1) | 38.2 (2.7) | 37.2 (2.6) | 35.3 (4.3) | 27.8 (4.4) |
| Bilirubin (µmol l−1) | 11.67 (3.33) | 15.00 (8.72) | 40.83 (12.64) | 67.00 (24.41) |
| PTT (s) | 0.17 (0.41) | 1.17 (1.17) | 2.83 (0.75) | 4.83 (1.72) |
| Encephalopathy (n) (None / 1 and 2) | 6/0 | 6/0 | 3/3 | |
| Ascites (n) | ||||
| Absent/slight/moderate | – | 6/0/0 | 4/2/0 | 2/0/4 |
| Portal vein (mm) | 10.3 (0.8) | 12.5 (1.0) | 13.6 (1.9) | 11.8 (0.8) |
Data are presented as mean (SD), or as number of patients, denoted (n). BMI, body mass index; PTT, partial thromboplastin time.