Table 1.
Overview microarray experiments: experimental model systems: HUVEC, human umbilical vein epithelial cells; PFF, primary foreskin fibroblasts; PrSC, primary prostatic stromal fibroblasts; RPTEC, renal proximal tubular epithelial cells; CD8, CD8+ T lymphocytes; MSC, mesenchymal stem cells; reagents: t-BHP (tert-butylhydroperoxide), FCCP (carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone), AMP (adenosine monophosphate); number of array hybridizations/samples; number of array experiments for senescence and oxidative stress; EMBL-EBI Array Express accession number
Controls |
Experimental group 1 (oxidative stress) |
Experimental group 2 (cellular aging) |
||||
---|---|---|---|---|---|---|
Celltype | No. of arrays | Treatment | No. of arrays | Treatment | No. of arrays | Array Express accession number |
HUVEC | 6 | t-BHP | 2 | RS | 2 | E-MEXP-2283 |
PFF | 8 | ND | ND | FCCP | 2 | E-MEXP-2285 |
AMP | 2 | |||||
Oligomycin | 2 | |||||
RPTEC | 4 | ND | ND | RS | 1 | E-MEXP-2683 |
High/low ROS | 1 | |||||
PrSC | 10 | t-BHP | 2 | TGF-β (trans-differentiation) | 2 | E-MEXP-2167 |
20% vs. 3% O2 | 4 | |||||
CD8 | 15 | t-BHP | 7 | CD28−/CD28+ | 4 | E-MEXP-2345 |
MSC | 4 | 20% vs. 3% O2 | 2 | Young vs. old donor | 2 | E-MEXP-1506 |
Total | 47 | 17 | 18 |
RS, replicative senescence; ND, not determined.