Table 2.
cis-Association and Psoriasis Association Meta-Analysis Results for the Eight Independent Skin eQTL SNPs with the Most Significant Psoriasis Association
| Marker |
cis-Association |
Psoriasis GWAS |
||||||
|---|---|---|---|---|---|---|---|---|
| cis-Associated Gene |
cis-Association p Value |
Alleles Risk/Nonrisk | Risk Allele Frequency | OR | Meta p Valuea | |||
| Normal | Uninvolved | Lesional | ||||||
| rs492602 | FUT2 | 1.5 × 10−4 | 1.9 × 10−6 | 1.0 × 10−9 | G/A | 0.482 | 1.169 | 2.7 × 10−4 |
| rs12039309 | TMEM77 | 3.2 × 10−7 | 5.3 × 10−6 | 2.7 × 10−5 | G/T | 0.271 | 1.212 | 8.5 × 10−4 |
| rs11171739 | RPS26 | 1.3 × 10−5 | 6.8 × 10−11 | 2.1 × 10−10 | C/T | 0.418 | 1.174 | 8.7 × 10−4 |
| rs13008446 | LOC348751 | 1.9 × 10−6 | 1.7 × 10−4 | 1.3 × 10−7 | A/G | 0.655 | 1.191 | 1.4 × 10−3 |
| rs8082268 | C17orf45 | 1.0 × 10−7 | 6.7 × 10−7 | 4.4 × 10−5 | C/T | 0.651 | 1.188 | 2.4 × 10−3 |
| rs2910686 | ERAP2 | 5.6 × 10−11 | 8.5 × 10−11 | 6.1 × 10−11 | C/T | 0.427 | 1.144 | 2.7 × 10−3 |
| rs139910 | TNRC6B | 2.6 × 10−7 | 5.0 × 10−4 | 3.3 × 10−2 | C/G | 0.744 | 1.117 | 4.1 × 10−3 |
| rs503612 | ENDOD1 | 2.9 × 10−9 | 9.6 × 10−9 | 6.9 × 10−9 | C/A | 0.564 | 1.148 | 4.8 × 10−3 |
a
The p value from the psoriasis GWAS meta-analysis (GAIN study + Kiel study). For all eight SNPs, the effect directions are consistent in the two studies of the meta-analysis.