Fig. 2.

The time course alteration of proinflammatory cytokines mRNA on KA injection in the hippocampus. Alteration of IL-1β, TNF-α (B), IL-6 (C), and COX-2 (D) mRNA at 1, 3, 6, 12, 24 hrs after intracerebral (i.c.v.) KA (0.1 µg/5 µl) injectio was examined in the hippocampus. Control group (CON) was injected with i.c.v. PBS. The mice number of each group was 3. Experiments were conducted independently three times, giving a total of nine per group in the final statistical analysis. ^**p<0.01(CON vs other groups), ^***p<0.001 (CON vs other groups).