Fig. 6.

Comparison of ICC distribution between normal and cancerous tissue of human stomach. Distribution of ICC is compared between normal (A) and cancerous tissue (B) obtained from a patient who underwent pancreotomy and gastrectomy. c-Kit positive ICC is observed in every layer; submucosa (Aa, Ba), circular muscle (Ab, Bb), myenteric area (Ac, Bc), and longitudinal muscle (Ad, Bd). Note that c-Kit positive immunoreactivity is found also in gastric mucosa of cancer area (Ba) as well as normal area (Aa). Arrow: processes or ramification, arrow head: central cell body, double arrow head: ICC in septa (ICC-SEP).