Fig. 2.

Effects of 5-HT receptor subtype-specific agonists and antagonists on the induction of LTD. LFS was applied with the stimulus duration of 0.2-msec to the slices from 5-week-old rats. (A) LFS was applied in the presence of 8-OH-DPAT (10 µM) (closed circle, 'DPAT,' n=10) or 5-HT (10 µM)+NAN-190 (10 µM) (open circle, '5-HT+NAN,' n=7). (B) LFS was applied in the presence of DOI (10 µM) (closed circle, 'DOI,' n=9), 5-HT (10 µM)+mesulergine (10 µM) (open circle, '5-HT+Mes,' n=7) or 5-HT (10 µM)+ketanserin (10 µM) (open square, '5-HT+Ket,' n=8). (C) LFS was applied in the presence of 2-me-5-HT (30 µM) (closed circle, '2-me-5-HT,' n=7). Insets show average traces taken from a representative experiment at the indicated period. Right panels plot individual data (symbols) and averages (thick solid lines). ^*p<0.05 and ^**p<0.01 vs. the baseline response.