Table 1.

Anti-influenza virus A (H3N2) activity of amantadine 1 and some aminoadamantane analogues 5 - 7^a in MDCK^b

Compounda	EC50 (μM)c,d
5	8.58 ± 2.79
6	45.6 ± 4.03
7	> 100
Amantadine, 1	3.35 ± 0.89

Abbreviations and notes:

^aAmantadine 1 was tested as hydrochloride salt, 5, 7 as dimaleate and 6 as monomaleate salts

^binfluenza A H₃N₂ (A/Hong Kong/68

^cConcentration required to reduce virus-induced cytopathic effect in MDCK (Madin-Darby canine kidney) cells by 50%

^dData are shown as mean ± SD of three independent determinations.