Fig. 7.

Detection of peribronchial cells coexpressing bFGF and TGF-β1. a Lungs from different groups of mice (n = 16 mice/group) were processed for immunohistochemistry with an anti-FGF receptor-1 Ab. The number of FGF receptor-1+ cells/bronchus was quantitated by image analysis. b Levels of lung TGF-β1 were quantitated by ELISA in specimens derived from different groups of mice (n = 16 mice/group). Mice chronically challenged with OVA had peribronchial cells expressing bFGF (red immunofluorescence; c) as well as TGF-β1 (green immunofluorescence; d). Peribronchial cells expressing both bFGF and TGF-β1 demonstrated yellow immunofluorescence (e). Neither bFGF (f) nor TGF-β1 (g) were detected by immunohistochemistry in peripheral blood mononuclear cells derived from OVA-challenged mice. CS = Corticosteroids.