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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Radiother Oncol. 2010 Oct 20;97(3):370–376. doi: 10.1016/j.radonc.2010.09.013

Table 2. Schema for RTOG 0933, a phase II trial of hippocampal avoidance during WBRT (HA-WBRT) for patients with brain metastases.

The primary endpoint will be delayed recall, assessed using the Hopkins Verbal Learning Test at 4 months after HA-WBRT. A planned statistical comparison will be made to an historical control of patients who received WBRT without hippocampal avoidance.

For Patients with MRI Evidence of Brain Metastasis Within 1 Month of WBRT
REGISTER1 Within 2 Weeks Prior to Treatment
 Radiation Therapy

  1. 3D SPGR MRI with Fused CT Simulation2

  2. Cognitive Testing

  3. Quality of Life Assessment

  4. Rapid Central Review of Hippocampal Contours and HA-WBRT Treatment Plan3

 WBRT with Hippocampal Avoidance using IMRT (30 Gy in 10 Fractions)4

Abbreviations: WBRT, whole-brain radiotherapy; 3D SPGR MRI, three-dimensional spoiled-gradient magnetic resonance imaging; IMRT, intensity-modulated radiotherapy.