Table 2.
Class | Compounds | HDACs | Status | Reference |
---|---|---|---|---|
Aliphatic acid | Valproic acid | Class I, IIa | Phase II clinical trials | [62] |
Benzamide | MGCD0103 | Class I, II | Phase II clinical trials | [63] |
Cyclic peptide | FK228 | Class I, II | FDA approved for CTCL | [64] |
Hydroxamates | SAHA | Class I, II | FDA approved for CTCL | [63] |
LBH589 | Class I, II | Phase II and III clinical trials | [23] | |
Trichostatin A | Class I, II | Experimental use | [65, 66] | |
Others | AR-42 | Class I, II | Started clinical trials | [67] |
CUDC101 | Class I, II | Started clinical trials | [68] |
Note: Valproic acid has been in use as an anticonvulsant and mood stabilizing drug in the treatment of epilepsy and bipolar disorder.