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Mammalian Members of HDAC Family.
| Mammalian HDACs | ||||
| Class | Homology to yeast | Mammalian members | Mechanism of catalysis | Cell localization |
| I | Rpd3 | HDAC1 | Zn2+ ion dependent | Ubiquitous |
| HDAC2 | ||||
| HDAC3 | ||||
| HDAC8 | ||||
| II | Hda1 | HDAC4 | Zn2+ ion dependent | |
| HDAC5 | ||||
| HDAC7 | Shuttle between | |||
| HDAC9 | nucleus and cytoplasm | |||
| HDAC6 | ||||
| HDAC10 | ||||
| III | Sir2 | SIRT1 | NAD+ dependent | Nucleus |
| SIRT2 | Cytoplasm | |||
| SIRT3 | Mitochondria | |||
| SIRT4 | Mitochondria | |||
| SIRT5 | Mitochondria | |||
| SIRT6 | Nucleus | |||
| SIRT7 | Nucleus | |||
| IV | HOS3 | HDAC11 | Zn2+ ion dependent | Nucleus |
