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. 2010 Jul 27;18(12):2146–2154. doi: 10.1038/mt.2010.164

Figure 2.

Figure 2

hGAA levels in liver, serum, and thymus after intravenous or intrathymic injection of AAV8-hGAA. Mice received different doses of the AAV8-hGAA vector by intravenous or intrathymic injection as in Figure 1. (a) Liver expression of the transgene was quantified at week 16 after AAV administration by hGAA mRNA copies. (b) Serum hGAA levels were determined by enzyme-linked immunosorbent assay at weeks 4 and 16, and (c) thymic expression was quantified at week 16 by hGAA mRNA copies. Data are expressed as means ± SEM (N = 8–10 mice/group).