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. Author manuscript; available in PMC: 2011 Nov 26.
Published in final edited form as: Circ Res. 2010 Oct 14;107(11):1336–1344. doi: 10.1161/CIRCRESAHA.110.227926

Figure 7. Proposed mechanism of miR-218 activity during blood vessel patterning.

Figure 7

The Slit2/3 genomic locus gives rise to both the Slit2/3 mRNAs and miR-218. Slit proteins are secreted and interact with the Robo receptor. miR-218 targets the Robo1/2 receptors and GLCE for inhibition. Reduced levels of GLCE alter HSPG biosynthesis, ultimately impinging upon the interaction between Slit and Robo. miR-218 links transcriptional activation of the Slit locus to the efficiency of Slit Robo signaling, ultimately controlling vascular patterning.