Skip to main content
. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Biotechnol Prog. 2010 Jul–Aug;26(4):1014–1023. doi: 10.1002/btpr.395

Figure 3. Steady-state operation of the CCBR at a constant inlet velocity of 6.5 cm/s at a RPM of 650 (A) and 920 (B).

Figure 3

The centrifugal and drag forces are at a balanced equilibrium (A) resulting in a cell bed volume of 5.5 mL and a cell density of 9.1 × 107 cells/mL. Increasing the RPM to 920 (B) doubles the centrifugal force, requiring a new equilibrium between the centrifugal and drag forces to be reached. As a result the cell bed volume is decreased to 3.4 mL and density is increased to 1.5 × 108 cells/mL.