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Immunolabeling for hyperphosphorylated tau co-localizes with perivascular neurons and activated microglia in Tg-SwDI/NOS2−/− mice. Brain sections from twelve months old Tg-SwDI mice or Tg-SwDI/NOS2−/− mice were immunolabeled for hyperphosphorylated tau using AT8 antibody (green). Neurons were identified using NeuN antibody (A-D), astrocytes using GFAP antibody (E-H), and activated microglia using the MHC II antibody (I-L). Scale bars = 20 µm.
