Figure 3.

Brain capillary amyloid deposition and associated pathology in Tg-SwDI/NOS2^−/− mice and human CAA Type 1. Brain sections from twelve months old Tg-SwDI/NOS2^−/− mice (A,B) and a case of human CAA Type 1 (D,E) were immunolabeled for collagen Type IV to identify capillaries (red) and stained with thioflavin S (green) to identify fibrillar amyloid (A,D) or immunolabeled for MHC II (brown) to identify activated microglia (B,E). Scale bars = 50 µm. Similarly, brain sections from twelve months old Tg-SwDI/NOS2^−/− mice (C) and a case of human CAA Type 1 (F) were immunolabeled for hyperphosphorylated tau using AT8 antibody (red) and stained with thioflavin S (green) to identify fibrillar amyloid. Scale bars = 20 µm.