Table 2.
Overview of reported single cases of malignant transformation of hepatocellular adenomas into hepatocellular carcinomas
| Reference | Year | Age/gener | Use and duration of OCs or steroids (years) | Number of HCAs and size at time of diagnosis of HCC | Time to HCA diagnosis (years)a | Interval between diagnosis of HCA and HCC (years) | Haemorrhage | Resected | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Tesluk and Lawrie26 | 1981 | 34/F | Yes, 5 | Solitary, 16 cm | 5 | 3 | Yes | Yes | Postoperative death after one month |
| Gordon et al.22 | 1986 | 36/F | Yes, 14 | Solitary, 13 cm | 14 | 3 | Yes | Yes | Disease free |
| Gyorffy et al.20 | 1989 | 53/F | Yes, 19 | Multiple (3), 12 cm | 19 | 2 | No | No | Tumour-related death after 7 months |
| Korula et al.195 | 1991 | 40/F | Yes, 15 | Solitary, 6.5 cm | 21 | None | No | Yes | Disease free |
| Ferrell196 | 1993 | 29/F | Yes, 0.5 | Solitary, 18 cm | 5 | None | No | Yes | Disease free |
| Foster and Bermanb19 | 1994 | 56/F | Yes, 10 | Multiple (3–4) | 10 | 5 | No | No | Tumour-related death after 5 months |
| Herman et al.197 | 1994 | 30/F | Yes, 15 | – | 15 | None | No | Yes | n/a |
| Herman et al.197 | 1994 | 37/F | Yes, 20 | – | 20 | None | No | Yes | n/a |
| Perret et al.198 | 1996 | 24/F | Yes, 3 | Solitary, 14 cm | 3 | None | No | Yes | Disease free |
| Scott et al.199 | 1996 | 22/M | No | Solitary, 6 cm | – | None | No | Yes | Disease free |
| Ye et al.21 | 1999 | 42/F | Yes, 25 | Multiple (2), 9 cm | 25 | None | Yes | Yes | Disease free |
| Larson et al.25 | 2002 | 52/M | No | Solitary, 12 cm | – | 11 | Yes | Yes | Recurrence after 6 years |
| Chuang et al.17 | 2002 | 19/M | Yes, 15c | – | 15 | None | No | Yes | n/a |
| Chuang et al.17 | 2002 | 46/F | No | Solitary, 10 cm | – | None | No | Yes | n/a |
| Ito et al.23 | 2003 | 57/F | Yes, 1 month | Solitary, 10 cm | 30 | None | Yes | Yes | Disease free |
| Burri et al.200 | 2006 | 40/F | Yes, 4.5 | Solitary, 6 cm | 16 | None | No | Yes | Disease free |
| Colovic et al.27 | 2007 | 70/F | No | Solitary, 11.5 cm | – | None | No | Yes | Disease free |
| Gorayski et al.18 | 2008 | 35/M | Yes, 2 | Solitary, 9 cm | 10 | None | No | Yes | Disease free |
| Kim et al.24 | 2009 | 53/M | No | Solitary, 4.5 cm | – | None | Yes | Yes | Disease free |
a
Time to HCA diagnosis since start of oral contraceptive therapy (which may has been discontinued before diagnosis).
b
This case is also enlisted in Table 1.
c
Oral prednisolone.
HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma; Ocs, oral contraceptives; –, no data available or not reported.