Figure 2.

Late-phase lipopolysaccharide (LPS) pretreatment attenuated liver parenchymal necrosis after ischaemia/reperfusion, whereas early-phase pretreatment was unable to prevent liver damage. Mice were subjected to LPS pretreatment, ischaemia and reperfusion as described above. Liver specimens were sampled 6 h after perfusion (n = 6). (A) Effect of LPS pretreatment on necrosis of hepatocytes following ischaemia/reperfusion was evaluated according to the pathological damage score. (B) Liver sections of each group (haematoxylin and eosin stain; original magnification × 100). Results are expressed as mean ± standard error of the mean. *P < 0.05, compared with the LPC(−) group and the Early-LPC group. LPC(−), LPS-non-treated group; Late-LPC, late-phase LPS preconditioning group; Early-LPC, early-phase LPS preconditioning group