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. Author manuscript; available in PMC: 2010 Dec 6.
Published in final edited form as: Science. 2010 Feb 26;327(5969):1098–1102. doi: 10.1126/science.1178334

Fig. 2.

Fig. 2

Flexibility and Plasticity of Helper T cells. Recent studies of Th cells have revealed more flexibility in cytokine production than predicted by earlier work and there are now many examples of plasticity of Th cell phenotype. CD4+ T cells can change their profile of cytokine production (dotted lines) and there are now circumstances in which the expression of master regulators is transient or instances where cells express more than one master regulator. New subsets are also recognized such as Th9 and Th22 cells, which selectively produce IL-9 and IL-22 respectively.