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. 2010 Jul 5;29(36):5032–5047. doi: 10.1038/onc.2010.250

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Copyright © 2010 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Downregulation of ARRDC3 is an early event in carcinogenesis. Oncomine was used to analyze previously published microarray data. (a) Levels of ARRDC3 mRNA are decreased in human breast cancers when compared with normal breast tissue. (b) ARRDC3 mRNA levels decrease in human mammary epithelial cells after transformation with various oncogenes. (c) Levels of ARRDC3 mRNA are decreased in metastatic lesions when compared with the primary tumor in the same patient. (d) Expression of ARRDC3 mRNA is decreased in the initial ER+ tumors from patients that have relapsed when compared with 5-year disease-free patients. All data, including P-values, were calculated from Oncomine.