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. 2010 Jul 5;29(36):5032–5047. doi: 10.1038/onc.2010.250

Figure 9.

Figure 9

Expression of ARRDC3 in human breast tumors. (a) Western blot analysis of protein extracts from primary human breast tumors (invasive ductal carcinomas). ARRDC3 and ITGβ4 expression are inversely correlated. (b–f) Immunofluorescence of primary breast or breast tumor tissue demonstrated an inverse correlation to ARRDC3 and ITGβ4 protein levels. (b) ARRDC3 is primarily expressed in the luminal cells in normal breast tissue. (c) Grade 1 breast tumors tend to express high levels of ARRDC3 and low levels of ITGβ4. (d) Grade 2 human breast tumors showed varied expression levels of ARRDC3. Expression is always the inverse of ITGβ4 expression. (e) Grade 3 breast tumors tend to express low or undetectable levels of ARRDC3 and high levels of ITGβ4. (f) Basal breast cancers with high ITGβ4 expression express very low or no levels of ARRDC3.